2016年，独立开发者ConcernedApe历时四年独自开发的《星露谷物语》正式发售。这款像素风格的种田模拟游戏，凭借细腻的玩法设计和温柔的情感内核，迅速席卷全球，销量突破3000万份，在Steam上长期位居口碑榜前列，也在中国掀起了一股种田游戏热潮。它向所有独立开发者证明了一件事：哪怕只有一个人，也能做出改变行业的作品。
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Before agar, microbiologists had experimented with other foodstuffs as microbial media. They turned to substances rich in the starches, proteins, sugars, fats, and minerals that organisms need for growth, testing with broths, bread, potatoes, polenta, egg whites, coagulated blood serums, and gelatine. However, none worked particularly well: all were easily broken down by heat and microbial enzymes, and their surface, once colonized, became mushy and unsuitable for isolating microbes.